Rheumatology Focused Clinical Research
Comprehensive rheumatology trial support across inflammatory arthritis, systemic autoimmune diseases, and connective tissue disorders — with expertise in composite response endpoints and immunogenicity assessments.
Expertise in Autoimmune & Inflammatory Research
Rheumatic diseases represent a rapidly evolving therapeutic area, driven by advances in biologic therapies, targeted synthetic DMARDs, and emerging cell therapies. Omega CRO provides comprehensive support for rheumatology clinical trials, combining deep therapeutic expertise with specialized laboratory capabilities through the Omega ecosystem.
Our experience encompasses the full spectrum of inflammatory and autoimmune rheumatic diseases. We understand the complexities of composite response criteria (ACR20/50/70, DAS28, PASI), the importance of immunogenicity testing for biologics, and the need for sensitive imaging modalities to detect subclinical disease activity.
Rheumatologic Indications
Inflammatory Arthritis
- Rheumatoid Arthritis (RA)
- Psoriatic Arthritis (PsA)
- Axial Spondyloarthritis (AS/non-radiographic axSpA)
- Juvenile Idiopathic Arthritis (JIA)
Systemic Autoimmune
- Systemic Lupus Erythematosus (SLE)
- Systemic Sclerosis (Scleroderma)
- Sjögren's Syndrome
- ANCA-Associated Vasculitis
Emerancing Areas
- Psoriasis (Dermatology crossover)
- Hidradenitis Suppurativa
- IgA Nephropathy
- Osteoarthritis & Bone Health
Composite Endpoints & Immunogenicity
Composite Response Criteria
- ACR20/50/70 response criteria for RA
- DAS28, CDAI, SDAI for disease activity
- ASAS response criteria for axial SpA
- SLEDAI, BICLA, SRI-4/6 for lupus
- Centralized joint counting and imaging review
Immunogenicity & Autoantibody Testing
- ELISA-based ADA (anti-drug antibody) screening and confirmation
- Cell-based neutralizing antibody (NAb) assays
- Rheumatoid factor (RF) and anti-CCP testing
- ANA, anti-dsDNA, anti-Smith, complement C3/C4
- ANCA (MPO/PR3) and cryoglobulin testing
Biologics, Biosimilars & Targeted Therapies
Extensive experience across all major therapeutic classes used in rheumatology trials.
Application Scenarios in the Omega Ecosystem
How the Omega ecosystem supports rheumatology research\u2014from immunogenicity testing to autoantibody profiling and joint imaging coordination.
HelixLab
Inflammatory & Safety Panels
CRP (high-sensitivity), ESR, complement C3/C4, serum immunoglobulin levels, comprehensive safety panels, and drug trough level monitoring for biologic and JAK inhibitor trials.
Omega Genetics
HLA Typing & Risk Variants
HLA-B27 for axial spondyloarthritis stratification; HLA-DRB1 shared epitope for RA prognosis; PTPN22, STAT4, and IRF5 variants informing autoimmune disease patient selection.
Omega Biorepository
Serum & Synovial Fluid Archive
Serial serum and synovial fluid (where applicable) biobanking at -80\u00b0C for retrospective biomarker analysis, ADA re-testing, and translational immunology research.
Omega Care
Remote PRO & Joint Counts
Home-based DAS28, HAQ-DI, and pain NRS capture via mobile platform; wearable activity monitoring for RA and PsA patients; telemedicine joint assessment coordination.
Omega Bio
ADA & NAb Assay Kits
Kit-based ELISA harmonization for anti-drug antibody (ADA) screening and confirmation; cell-based neutralizing antibody (NAb) assay standardization across multi-center biologic trials.
Animal Facility
Arthritis & Lupus Models
Collagen-induced arthritis (CIA) models, adjuvant-induced arthritis, and NZB/W F1 lupus models for preclinical evaluation of biologics, JAK inhibitors, and emerging cell therapies.
Drive Your Rheumatology Trial Forward
Partner with Omega CRO for integrated rheumatology expertise, specialized laboratory services, and proven operational excellence.
Talk to Our Experts